Dr. Riina Gröhn

Written on maiden name Kekkonen.

Peer-reviewed scientific articles

Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P, de Vos WM. Intestinal microbiome use is related to lifetime antibiotic use in Finnish pre-school children. Nat Commun 2016; 7: 10410.

Kolmeder CA, Salojärvi J, Ritari J, de Been M, Raes J, Falony G, Vieira-Silva S, Kekkonen RA, Corthals G, Palva A, Salonen A, de Vos WM. Faecal Metaproteomic Analysis Reveals a Personalized and Stable Functional Microbiome and Limited Effects of a Probiotic Intervention in Adults. PLoS One. 2016 Apr 12;11(4):e0153294. doi: 10.1371/journal.pone.0153294.

Korpela K, Salonen A, Virta LJ, Kekkonen RA, de Vos WM. Lactobacillus rhamnosus GG intake modifies preschool children’s intestinal microbiota, alleviates penicillin-associated changes, and reduces antibiotic use. PlosOne 2016, Apr 16. http://dx.doi.org/10.1371/journal.pone.0154012

Kumpu M, Viitala R, Korpela R, Tynkkynen S, Järvenpää S, Kautiainen H,  Allen EK, Hendley O, Pitkäranta A, Winther B. Effect of live and inactivated Lactobacillus rhamnosus GG on experimentally induced rhinovirus colds: Randomized, double blind, placebo-controlled trial. Beneficial Microbes 2015; 6(5):631-639.

Vuolteenaho K, Leppänen T, Kekkonen R, Korpela R, Moilanen E. Running a marathon induces changes in adipokine levels and in markers of cartilage degradation – novel role for resistin. PLoS One. 2014 Oct 21;9(10):e110481. doi: 10.1371/journal.pone.0110481.

Holma R, Kekkonen RA, Hatakka K, Poussa T, Vapaatalo H, Adlercreutz H, Korpela R. Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a symbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study. Br J Nutr. 2014 Jan 28;111(2):301-9.

Hidalgo-Cantabrana C, Kekkonen R, de los Reyes-Gavilan CG, Salminen S, Korpela R, Gueimonde M, Ruas-Madiedo P. Effect of bacteria used in food industry on the proliferation and cytokine production of epithelial intestinal cellular lines. Journal of Functional Foods 2014;6:348-335

Lahti L, Salonen A, Kekkonen RA, Salojärvi J, Jalanka-Tuovinen J, Palva A, Orešič M, de Vos WM. Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data. PeerJ. 2013 Feb 26;1:e32. doi: 10.7717/peerj.32. Print 2013.

Oksaharju A, Kooistra T, Kleemann R, van Duyvenvoorde W, Miettinen M, Lappalainen J, Lindstedt KA, Kovanen PT, Korpela R, Kekkonen RA. Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet. Br J Nutr. 2013 Jul;110(1):77-85.

Kumpu M, Lehtoranta L, Roivainen M, Rönkkö E, Ziegler T, Söderlund-Venermo M, Kautiainen H, Järvenpää S, Kekkonen R, Hatakka K, Korpela R, Pitkäranta A. The use of the probiotic Lactobacillus rhamnosus GG and viral findings in the nasopharynx of children attending day care. J Med Virol. 2013 Sep;85(9):1632-8.

Kumpu M, Swanljung E, Tynkkynen S, Hatakka K, Kekkonen RA, Järvenpää S, Korpela R, Pitkäranta A. Recovery of probiotic Lactobacillus rhamnosus GG in tonsil tissue after oral administration: randomised, placebo-controlled, double-blind clinical trial. Br J Nutr. 2013 Jun;109(12):2240-6.

Kumpu M, Kekkonen RA, Kautiainen H, Järvenpää S, Kristo A, Huovinen P, Pitkäranta A, Korpela R, Hatakka K. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2012 Sep;66(9):1020-3.

Miettinen M, Pietilä TE, Kekkonen RA, Kankainen M, Latvala S, Pirhonen J, Österlund P, Korpela R, Julkunen I. Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages. Gut Microbes. 2012 Nov-Dec;3(6):510-22.

Välimäki IA, Vuorimaa T, Ahotupa M, Kekkonen R, Korpela R, Vasankari T. Decreased training volume and increased carbohydrate intake increases oxidized LDL levels. Int J Sports Med. 2012 Apr;33(4):291-6.

Holma R, Kekkonen RA, Hatakka K, Poussa TA, Vaarala O, Adlercreutz H, Korpela R. Consumption of Galactooligosaccharides Together with Probiotics Stimulates the in vitro Peripheral Blood Mononuclear Cell Proliferation and IFNg Production in Healthy Men. ISRN Immunology, vol. 2011, Article ID 584682, 6 pages, 2011. doi:10.5402/2011/584682

Shi J, Ahlroos-Lehmus A, Pilvi TK, Kekkonen R, Korpela R, Mervaala EM. Comparison of the metabolic effects of milk-derived alactalbumin and amino acids mixture with equal composition in diet-induced obese mice. J Functional Foods 2011; 3: 70-78.

Jalanka-Tuovinen J, Salonen A, Nikkilä J, Immonen O, Kekkonen R, Lahti L, Palva A, de Vos WM. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One. 2011;6(7):e23035.

Rajilić-Stojanović M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S, de Vos WM. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterol. 2011 Nov;141(5):1792-801.

Björkman MP, Pilvi TK, Kekkonen RA, Korpela R, Tilvis RS. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health Aging. 2011;15(6):462-7.

Latvala S, Miettinen M, Kekkonen RA, Korpela R, Julkunen I. Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages. Clin Exp Immunol. 2011 Jul;165(1):94-103.

Kekkonen RA, Holma R, Hatakka K, Suomalainen T, Poussa T, Adlercreutz H, Korpela R. A probiotic mixture including galactooligosaccharides decreases fecal  {beta}-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention. J Nutr. 2011 May;141(5):870-6.

Oksaharju A, Kankainen M, Kekkonen RA, Lindstedt KA, Kovanen PT, Korpela R, Miettinen M. Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells. World J Gastroenterol. 2011 Feb 14;17(6):750-9.

Salonen A, Nikkilä J, Jalanka-Tuovinen J, Immonen O, Rajilić-Stojanović M, Kekkonen RA, Palva A, de Vos WM. Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis. J Microbiol Methods. 2010 May;81(2):127-34.

Lummela N, Kekkonen RA, Jauhiainen T, Pilvi TK, Tuure T, Järvenpää S, Eriksson JG, Korpela R. Effects of a fibre enriched milk-drink on insulin and glucose levels in healthy subjects. Nutr J 2009; Oct 1; 8:45.

Kekkonen R. Immunomodulatory effects of probiotics. Austr J Dairy Techol 2009;46(1):128-132.

Latvala S, Pietilä TE, Veckman V, Kekkonen RA, Tynkkynen S, Korpela R, Julkunen I. Probiotic bacteria efficiently induce dendritic cell maturation but show clear differences in their ability to induce cytokine production in human monocyte-derived dendritic cells. World J Gastroenterol 2008;14:5570-5583.

Piirainen L, Kekkonen RA, Kajander K, Alhroos T, Tynkkynen S, Nevala R and Korpela R. In school-aged children a combination of galacto-oligosaccharides and Lactobacillus rhamnosus GG increases bifidobacteria more than Lactobacillus rhamnosus GG on its own. Ann Nutr Metab 2008;52:204-208.

Kekkonen RA, Sysi-Aho M, Seppänen-Laakso T, Julkunen I, Vapaatalo H, Oresic M, Korpela R. Effect of probiotic Lactobacillus rhamnosus GG intervention on serum global lipidomics profiles in healthy adults. World J Gastroenterol 2008;14:3188-3194.

Kekkonen RA, Lummela N, Karjalainen H, Latvala S, Tynkkynen S, Järvenpää S, Kautiainen H, Julkunen I, Vapaatalo H, Korpela R. Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults. World J Gastroenterol 2008;14:2029-2036.

Kekkonen RA, Kajasto E, Miettinen M, Veckman V, Korpela R, Julkunen I. Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-g production. World J Gastroenterol 2008;14:1192-1203.

Kekkonen RA, Vasankari TJ, Vuorimaa T, Haahtela T, Julkunen I, Korpela R. The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners. Int J Sports Nutr Exerc Metab 2007;17:352-363.

Moreira A, Kekkonen R, Korpela R, Delgado L, Haahtela T. Allergy in marathon runners and effect of Lactobacillus GGsupplementation on allergic inflammatory markers. Respir Med 2007;101:1123-1131.

Kekkonen RA, Ahlroos T, Suomalainen T, Tynkkynen S, Poussa T, Nevala R, Korpela R. A combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria to a greater extent than Lactobacillus GG on its own. Milk Sci Int (Milchwissenschaft) 2007;62:326-330.

Moreira A, Kekkonen RA, Delgado L, Fonseca J, Korpela R, Haahtela T. Nutritional modulation of exercise induced immunodepression in athletes: a systematic review and meta-analysis. Eur J Clin Nutr 2007;61:443-460.

Conference abstracts

Latvala S, Miettinen M, Kekkonen R, Korpela R, Julkunen I. Potentially probiotic bacteria induce inflammasome activation and cytokine production in human monocyte-derived macrophages. [abstract] European Congress of Clinical Microbiology and Infectious Diseases. 16 - 19.5.2009, Helsinki, Finland

Kekkonen R. Dairy components and products for weight management and metabolic syndrome. [abstract] IDF Dairy Science and Technology Week / Novalait Technological Forum
May, 12-16 2008, Quebec, Canada

Kekkonen RA. Probiotics and immune response – toward a systems biology approach. [abstract] 1st Varna Nutrigenomics Meeting 18th-20th of October 2007, Varna, Bulgaria.

Latvala S, Pietilä T, Kekkonen R, Korpela R, Julkunen I. Probiotic bacteria can induce the maturation and cytokine gene expression in human monocyte-derived dendritic cells. [abstract] SSA GutImpact 3rd Platform Meeting 29th-31th of August 2007, Haikko, Finland.

Latvala S, Pietilä T, Kekkonen R, Korpela R, Julkunen I. Probiotic bacteria can induce the maturation and cytokine gene expression in human monocyte-derived dendritic cells. [abstract] Scandinavian Society for Immunology Meeting, 6th-9th of June 2007, Turku, Finland.

Kekkonen R, Jauhiainen T, Lummela N, Tuure T. Effects of a fiber enriched milk drink and fat-free milk on blood glucose levels in healthy subjects after a meal [abstract] ECO 2007.

Lummela N, Kekkonen R, Järvenpää S, Eriksson J, Korpela R. Effects of a fibre-enriched milk-drink on blood glucose and insulin levels and subjective satiety in healthy subjects [abstract] ECO 2007.

Kekkonen R, Jauhiainen T, Lummela N, Tuure T. Effects of a fiber enriched milk drink and fat-free milk on blood glucose levels in healthy subjects [abstract] ECO 2007.

Korpela R, Kajander K, Tynkkynen S, Kekkonen R, Myllyluoma E, Saxelin M. How to develop a new probiotic combination [abstract] NSA, Sydney, Australia 2006.

Kekkonen RA, Kajasto E, Veckman V, Miettinen M, Korpela R, Julkunen I. Probiotic bacteria induce a differential cytokine production pattern in human peripheral blood mononuclear cells [abstract] 6th Louis Pasteur Conference on Infectious Diseases – Shaping and Subversion of the Immune system by microbes. Paris, France, 15.-17.11.2006.

Kekkonen R, Kajasto E, Veckman V, Miettinen M, Korpela R, Julkunen I. Julkunen. Probiotic bacteria induce a differential cytokine production pattern in human peripheral blood mononuclear cells [abstract] 2nd SSA GutImpact conference, Tallinn, Estonia, 27.-29.9.2006.

Ahotupa M, Saxelin M, Kekkonen R, Korpela R. Probiotics as potential antioxidant protectors of the gut: the effects of Lactobacillus GG [abstract]  2nd SSA GutImpact conference, Tallinn, Estonia, 27.-29.9.2006.

Kekkonen R, Kajasto E, Veckman V, Miettinen M, Korpela R, Julkunen I. Probiotic bacteria induce a differential cytokine production pattern in human peripheral blood mononuclear cells [abstract] IUFOST 17.-21.9.2006, Nantes, France.

Kekkonen R, Jauhiainen T, Lummela N, Tuure T. Effects of a fiber enriched milk drink and fat-free milk on blood glucose levels in healthy subjects [abstract] Neuroendocrinological regulation of food intake. 11-12 May, 2006, Kuopio, Finland.

Kajander K, Kekkonen R, Ahlroos T, Tynkkynen S, Nevala R, Suomalainen T and Korpela R. Administration of Lactobacillus GG and galacto-oligosaccharides increase faecal bifidobacteria in 6-10 -year-old children more than Lactobacillus GG alone [abstract]. In: Törrönen R, Gylling H, eds. The 20th Anniversary Symposium of The Department of Clinical Nutrition, March 18-19, 2004. Kuopio University Publications D. Medical Sciences 325, 2004, p. 24.

Kekkonen R, Halme T, Suomalainen T, Tynkkynen S, Poussa T, Nevala R, Korpela R. A combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria to a greater extent than Lactobacillus GG on its own [abstract] 2nd Probiotics & Prebiotics & New Foods Conference, Rome, Italy, 7.-9.9.2003.

Doctoral thesis and pro gradu thesis

Kekkonen R. Immunomodulatory effects of probiotic bacteria in healthy adults (Thesis). University of Helsinki, Helsinki University Print, Helsinki 2008.

Kekkonen R. Liikunnan yhteydet antropometrisiin muuttujiin, sydän- ja verisuonitautien vaaratekijöihin ja ravintoaineiden saantiin suomalaisessa diabeteksen ehkäisytutkimuksessa (DPS). (Pro Gradu thesis) 16.5. 2002 [in Finnish]

Books

Kekkonen R, Peuhkuri K. Chapter 9: Bioactive milk protein and peptide functionality. In Corredig M (ed) Dairy-derived ingredients – Food and nutraceutical uses. Woodhead Publishing Ltd, Cambridge, England, 2009, p.238-268.

Kekkonen R, Tuure T. Chapter 22: Developing dairy weight management products. In Saarela M (ed) Functional Dairy Products, vol. 2, Woodhead Publishing Ltd, Cambridge, England, 2007, p. 496-505.

Holla T, Kekkonen R, Koivisto P, Rajala A-L. Sydänliiton ruoka-ainetaulukko, 3. uudistettu painos. Gummerus Kirjapaino Oy, Jyväskylä 2002. [in Finnish]